A complex sample matrix is the bane of analytical chemistry, and it’s why we go through such pains in sample preparation and GC method development to reduce the background interference and isolate our analytes of interest. It’s the proverbial needle in the haystack problem. And if you’re dealing with an unresolved complex matrix, or “hump-o-gram”? Forget it! Even if you can find your target in the mess, how do you integrate it? What baseline do you choose?