Norman Fraley, Principal Chemist Eurofins - Lancaster Laboratories
I hate derivatization. That being said, I love derivatization. What is there not to love about such an elegant chemical reaction where the purpose is to create something new from reagents you have just so you can see it and measure it better? Is your target compound thermally unstable? Derivatize it. Not volatile enough? Derivatize it. Your detector cannot see it well? Derivatize it. Is it too volatile? Yes, you guessed right – derivatize it. In my 30 years of analytical chemistry I have not found a more handy technique, although that does not mean it is simple or easy.